Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.55 |
| ▸ | CASP3 | P42574 | 5/20 | 0.49 |
| ▸ | TGM2 | P21980 | 5/20 | 0.49 |
| ▸ | CES1 | P23141 | 3/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.47 |
| ▸ | CASP9 | P55211 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CAPN9 | O14815 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9098040 | 1.00 | EPHX2 (0.55) | EPHX2CASP3TGM2CES1CASP1 | |
| SCHEMBL9097437 | 0.98 | EPHX2 (0.53) | EPHX2CASP3TGM2CES1CASP1 | |
| SCHEMBL1768001 | 0.92 | TGM2 (0.53) | CASP3TGM2CES1CASP1CASP7 | |
| Bicarbonate SCHEMBL1768040 | 0.89 | MAOA (0.45) | EPHX2CASP3TGM2CES1CASP1 | |
| Formic Acid SCHEMBL27886080 | 0.88 | TGM2 (0.44) | EPHX2CASP3TGM2CES1CASP1 | |
| SCHEMBL9389080 | 0.88 | EPHX2 (0.78) | EPHX2CASP3TGM2CES1CASP1 | |
| Bicarbonate SCHEMBL1768126 | 0.86 | MAOA (0.47) | CASP3TGM2CES1CASP1CASP7 | |
| SCHEMBL25826016 | 0.81 | EPHX2 (0.49) | EPHX2TGM2HSP90AA1GAAMAPT | |
| SCHEMBL25825365 | 0.80 | MAPT (0.48) | EPHX2TGM2HSP90AA1GAAMAPT | |
| SCHEMBL11519137 | 0.78 | MAOA (0.55) | EPHX2CASP3MAOAMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585378-A | Composition containing an oxoindole compound | AKTIEBOLAGET ASTRA (SE) | 1996-12-17 | — | — | US | disclosed |
| EP-0703901-A1 | 1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE | Astra Aktiebolag (SE) | 1996-04-03 | — | — | EP | disclosed |
| WO-1994029272-A1 | 1-SUBSTITUTED ISATIN AND OXINDOLE DERIVATIVES AS INHIBITORS OF ACETYLCHOLINESTERASE | ASTRA AKTIEBOLAG (SE) | 1994-12-22 | — | — | WO | disclosed |
| EP-0624156-A1 | ISATIN DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | Astra Aktiebolag (SE) | 1994-11-17 | — | — | EP | disclosed |
| CN-1079464-A | Treatment comprises the preparation method of the valuable indolone of illness of cholinergic function reduction and the derivative of indole dione | ASTRA AB (SE) | 1993-12-15 | — | — | CN | disclosed |
| WO-1993012085-A1 | ISATIN DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | AKTIEBOLAGET ASTRA (SE) | 1993-06-24 | — | — | WO | disclosed |
| CN-1009197-B | Process for preparing N, 3-disubstituted 2-oxindole-1-carboxamides | PFIZER (US) | 1990-08-15 | — | — | CN | disclosed |
| CN-85103527-A | Preparation N, the method for the disubstituted 2-hydroxyindole of 3--1-hydroxyalkyl cooh amide | — | 1987-01-28 | — | — | CN | disclosed |