Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 6/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.41 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.41 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25825383 | 0.88 | ALDH1A1 (0.47) | ALDH1A1HIF1AVCAM1GPR35HTT | |
| SCHEMBL9107069 | 0.83 | ALDH1A1 (0.46) | ALDH1A1HIF1AVCAM1GPR35HTT | |
| SCHEMBL2646002 | 0.83 | ALDH1A1 (0.56) | ALDH1A1HIF1AVCAM1GPR35HTT | |
| SCHEMBL29739450 | 0.83 | ALDH1A1 (0.56) | ALDH1A1HIF1AVCAM1GPR35HTT | |
| SCHEMBL25825634 | 0.82 | ALDH1A1 (0.45) | ALDH1A1HIF1AVCAM1GPR35HTT | |
| SCHEMBL29739317 | 0.81 | ALDH1A1 (0.55) | ALDH1A1HIF1AVCAM1GPR35HTT | |
| SCHEMBL24711215 | 0.81 | MAPK1 (0.50) | ALDH1A1GPR35L3MBTL1LMNAMAPK1 | |
| SCHEMBL15157099 | 0.81 | TSHR (0.53) | ALDH1A1GPR35LMNAMAPK1ATM | |
| SCHEMBL18110843 | 0.80 | LMNA (0.44) | ALDH1A1HIF1AVCAM1GAAL3MBTL1 | |
| SCHEMBL18111314 | 0.79 | ALDH1A1 (0.42) | ALDH1A1HIF1AVCAM1HTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219942-A1 | COMPOUNDS COMPRISING A THREE RING CORE AS PD-1/PD-L1 BLOCKERS | RELIVE THERAPEUTICS INC. (CA) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219942-A1 | COMPOUNDS COMPRISING A THREE RING CORE AS PD-1/PD-L1 BLOCKERS | CD274, PDCD1, PDCD1LG2 | ALDH1A1 1303/4885HIF1A 281/4885VCAM1 26/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.