Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23999644 | 0.88 | MAPT (0.55) | MAPTCYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL24006305 | 0.87 | MAPT (0.53) | MAPTCYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL24005987 | 0.81 | MAPK10 (0.53) | MAPTCYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL25826013 | 0.80 | MAPKAPK2 (0.51) | MAPTCYP1A2CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL24005998 | 0.79 | MAPT (0.47) | MAPTCYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL24006299 | 0.79 | DNMT1 (0.56) | MAPTCYP1A2CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL23786568 | 0.78 | MAPT (0.59) | MAPTCYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL21853351 | 0.78 | MAPT (0.58) | MAPTCYP1A2CYP3A4CYP2D6MAPK1 | |
| SCHEMBL23999554 | 0.76 | MAPT (0.67) | MAPTMAPK1SMN1; SMN2POLBTSHR | |
| SCHEMBL8770431 | 0.74 | HDAC8 (0.81) | MAPTMAPK1SMN1; SMN2KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183226-A1 | AKT3 MODULATORS | Georgiamune Inc. | 2023-06-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183226-A1 | AKT3 MODULATORS | AKT3, AKT2, MTOR | MAPT 3999/4885CYP1A2 3870/4885CYP3A4 3846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.