Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.59 |
| ▸ | MRGPRX2 | Q96LB1 | 4/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18408180 | 1.00 | OPRM1 (0.59) | OPRM1OPRD1OPRK1SIGMAR1MRGPRX2 | |
| SCHEMBL1206692 | 1.00 | OPRM1 (0.59) | OPRM1OPRD1OPRK1SIGMAR1MRGPRX2 | |
| SCHEMBL1207273 | 0.80 | OPRM1 (0.60) | OPRM1OPRD1OPRK1SIGMAR1MRGPRX2 | |
| SCHEMBL18408074 | 0.80 | OPRM1 (0.60) | OPRM1OPRD1OPRK1SIGMAR1MRGPRX2 | |
| SCHEMBL18407995 | 0.80 | OPRD1 (0.63) | OPRM1OPRD1OPRK1SIGMAR1MRGPRX2 | |
| SCHEMBL1207662 | 0.80 | OPRD1 (0.63) | OPRM1OPRD1OPRK1SIGMAR1MRGPRX2 | |
| SCHEMBL18407971 | 0.80 | OPRM1 (0.57) | OPRM1OPRD1OPRK1SIGMAR1MRGPRX2 | |
| SCHEMBL18408225 | 0.80 | OPRM1 (0.57) | OPRM1OPRD1OPRK1SIGMAR1MRGPRX2 | |
| SCHEMBL1207656 | 0.80 | OPRM1 (0.57) | OPRM1OPRD1OPRK1SIGMAR1MRGPRX2 | |
| SCHEMBL1207890 | 0.80 | OPRM1 (0.57) | OPRM1OPRD1OPRK1SIGMAR1MRGPRX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245014-B1 | UREA DERIVATIVES OF BENZOMORPHANES AND RELATED SCAFFOLDS, MEDICAMENTS CONTAINING SUCH COMPOUNDS AND THEIR USE | BOEHRINGER INGELHEIM INT (DE) | 2011-11-02 | — | — | EP | disclosed |