Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EPHA2 | P29317 | 5/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | EBP | Q15125 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29762063 | 0.89 | PDK1 (0.43) | PDK1ALDH1A1TDP1SMN1; SMN2HRH3 | |
| SCHEMBL26621765 | 0.89 | PDK1 (0.41) | PDK1ALDH1A1TDP1SMN1; SMN2EPHA2 | |
| SCHEMBL25123425 | 0.88 | ALDH1A1 (0.53) | PDK1ALDH1A1TDP1SMN1; SMN2HRH3 | |
| SCHEMBL22837616 | 0.87 | PDK1 (0.41) | PDK1ALDH1A1TDP1SMN1; SMN2EPHA2 | |
| SCHEMBL26403991 | 0.87 | PDK1 (0.41) | PDK1ALDH1A1TDP1SMN1; SMN2EPHA2 | |
| SCHEMBL25468939 | 0.87 | PDK1 (0.53) | PDK1ALDH1A1TDP1SMN1; SMN2SIGMAR1 | |
| SCHEMBL26280853 | 0.85 | PDK1 (0.51) | PDK1ALDH1A1TDP1SMN1; SMN2EPHA2 | |
| SCHEMBL26280856 | 0.85 | PDK1 (0.51) | PDK1ALDH1A1TDP1SMN1; SMN2EPHA2 | |
| SCHEMBL24379939 | 0.85 | ALDH1A1 (0.40) | PDK1ALDH1A1TDP1SMN1; SMN2EPHA2 | |
| SCHEMBL24508737 | 0.85 | PDK1 (0.43) | PDK1ALDH1A1TDP1SMN1; SMN2EPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219945-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219945-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | PDK1 504/4885ALDH1A1 2776/4885TDP1 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.