Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 14/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17351670 | 0.91 | POLB (0.57) | POLBTDP1TRPM8NPC1TSHR | |
| SCHEMBL6122115 | 0.89 | L3MBTL1 (0.52) | POLBTDP1TRPM8NPC1RAB9A | |
| Alintegimod SCHEMBL6121788 | 0.86 | POLB (0.53) | POLBTDP1TRPM8NPC1TSHR | |
| SCHEMBL26619051 | 0.86 | POLB (0.53) | POLBTDP1TRPM8NPC1TSHR | |
| SCHEMBL24344577 | 0.85 | POLB (0.49) | POLBTDP1TRPM8TSHRCHRM2 | |
| SCHEMBL6122577 | 0.85 | POLB (0.51) | POLBTDP1TRPM8TSHRL3MBTL1 | |
| SCHEMBL24344598 | 0.82 | POLB (0.46) | POLBTDP1TRPM8TSHRCHRM2 | |
| SCHEMBL30669905 | 0.82 | POLB (0.51) | POLBTDP1TRPM8TSHRCHRM2 | |
| SCHEMBL12539260 | 0.82 | TRPM8 (0.62) | TRPM8 | |
| SCHEMBL24343791 | 0.81 | POLB (0.45) | POLBTDP1TRPM8NPC1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023018471-A9 | PIPERAZINE-BASED AGONISTS OF LFA-1 AND VLA-4 | TEXAS HEART INSTITUTE (US) | 2023-07-13 | — | — | WO | disclosed |