Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.46 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TNKS | O95271 | 14/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 14/20 | 0.35 |
| ▸ | PARP1 | P09874 | 13/20 | 0.35 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17782899 | 0.79 | MAPT (0.61) | ALDH1A1LMNAMAPTPOLBKDM4E | |
| SCHEMBL11737600 | 0.73 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTPOLBKDM4E | |
| SCHEMBL17272797 | 0.72 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTPOLBKDM4E | |
| SCHEMBL25834539 | 0.70 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPTPOLBKDM4E | |
| Ticlatone SCHEMBL30165586 | 0.69 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTPOLBKDM4E | |
| Ticlatone SCHEMBL193888 | 0.69 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTPOLBKDM4E | |
| SCHEMBL5807922 | 0.69 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTPOLBKDM4E | |
| SCHEMBL92265 | 0.69 | ALDH1A1 (0.56) | ALDH1A1LMNAMAPTPOLBKDM4E | |
| SCHEMBL6232500 | 0.68 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTPOLBKDM4E | |
| SCHEMBL79222 | 0.68 | ALDH1A1 (0.50) | ALDH1A1LMNAMAPTPOLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880666-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-06-28 | — | — | EP | disclosed |