Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | GBA1 | P04062 | 3/20 | 0.43 |
| ▸ | UGCG | Q16739 | 2/20 | 0.43 |
| ▸ | GBA2 | Q9HCG7 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NAAA | Q02083 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.42 |
| ▸ | TEAD3 | Q99594 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1109806 | 0.90 | TSHR (0.52) | L3MBTL1TDP1TSHRNAAASMN1; SMN2 | |
| SCHEMBL4663055 | 0.87 | L3MBTL1 (0.50) | L3MBTL1TDP1GBA1UGCGGBA2 | |
| SCHEMBL23405397 | 0.83 | TSHR (0.61) | L3MBTL1TDP1GBA1UGCGGBA2 | |
| SCHEMBL20535824 | 0.83 | TSHR (0.61) | L3MBTL1TDP1GBA1UGCGGBA2 | |
| SCHEMBL21184508 | 0.81 | TSHR (0.64) | L3MBTL1TDP1GBA1UGCGGBA2 | |
| SCHEMBL16595002 | 0.81 | TSHR (0.64) | L3MBTL1TDP1GBA1UGCGGBA2 | |
| SCHEMBL25195898 | 0.81 | TSHR (0.64) | L3MBTL1TDP1GBA1UGCGGBA2 | |
| SCHEMBL19040806 | 0.80 | L3MBTL1 (0.50) | L3MBTL1TDP1GBA1UGCGGBA2 | |
| SCHEMBL16594712 | 0.79 | TSHR (0.61) | L3MBTL1TDP1GBA1UGCGGBA2 | |
| SCHEMBL9011624 | 0.79 | TSHR (0.67) | L3MBTL1TDP1GBA1UGCGGBA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |