Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 6/20 | 0.50 |
| ▸ | TLR7 | Q9NYK1 | 6/20 | 0.50 |
| ▸ | TLR9 | Q9NR96 | 5/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31188127 | 1.00 | TLR8 (0.50) | TLR8TLR7TLR9DDB1CRBN | |
| SCHEMBL31017624 | 0.93 | DDB1 (0.49) | TLR8TLR7TLR9DDB1CRBN | |
| SCHEMBL25830951 | 0.93 | DDB1 (0.49) | TLR8TLR7TLR9DDB1CRBN | |
| SCHEMBL31017628 | 0.87 | PDE4B (0.50) | TLR8TLR7TLR9DDB1CRBN | |
| SCHEMBL25831121 | 0.87 | PDE4B (0.50) | TLR8TLR7TLR9DDB1CRBN | |
| SCHEMBL25831682 | 0.83 | DDB1 (0.49) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL25830759 | 0.83 | ALK (0.55) | MAPTNAMPTALKWNT3AMEN1 | |
| SCHEMBL31017632 | 0.83 | ALK (0.55) | MAPTNAMPTALKWNT3AMEN1 | |
| SCHEMBL31110468 | 0.80 | DDB1 (0.50) | TLR8TLR7TLR9DDB1CRBN | |
| SCHEMBL31017627 | 0.77 | CNR1 (0.48) | JAK1NAMPTALKWNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118414336-A | Degradation of Bruton Tyrosine Kinase (BTK) by conjugation of BTK inhibitors to E3 ligase ligands and methods of use | 百济神州有限公司 | 2024-07-30 | — | — | CN | disclosed |
| WO-2023125907-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2023-07-06 | — | — | WO | disclosed |