Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.49 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | WNT3A | P56704 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31017624 | 1.00 | DDB1 (0.49) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL25831121 | 0.94 | PDE4B (0.50) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL31017628 | 0.94 | PDE4B (0.50) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL25830811 | 0.93 | TLR8 (0.50) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL31188127 | 0.93 | TLR8 (0.50) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL25831682 | 0.85 | DDB1 (0.49) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL31017634 | 0.80 | PDE4B (0.50) | DDB1CRBNMAPTTLR9TLR8 | |
| SCHEMBL25831131 | 0.80 | PDE4B (0.50) | DDB1CRBNMAPTTLR9TLR8 | |
| SCHEMBL31110468 | 0.78 | DDB1 (0.50) | DDB1CRBNKDM4EMAPTTHRB | |
| SCHEMBL31017635 | 0.77 | JAK2 (0.55) | DDB1CRBNTLR9TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125907-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2023-07-06 | — | — | WO | disclosed |