Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | CCNK | O75909 | 1/20 | 0.43 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 4/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.40 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31017628 | 1.00 | PDE4B (0.50) | PDE4BDDB1CRBNCCNKCDK12 | |
| SCHEMBL25830951 | 0.94 | DDB1 (0.49) | PDE4BDDB1CRBNHPGDSJAK2 | |
| SCHEMBL31017624 | 0.94 | DDB1 (0.49) | PDE4BDDB1CRBNHPGDSJAK2 | |
| SCHEMBL25830811 | 0.87 | TLR8 (0.50) | PDE4BDDB1CRBNHPGDSJAK2 | |
| SCHEMBL31188127 | 0.87 | TLR8 (0.50) | PDE4BDDB1CRBNHPGDSJAK2 | |
| SCHEMBL31017634 | 0.85 | PDE4B (0.50) | PDE4BDDB1CRBNCCNKCDK12 | |
| SCHEMBL25831131 | 0.85 | PDE4B (0.50) | PDE4BDDB1CRBNCCNKCDK12 | |
| SCHEMBL22608999 | 0.81 | PDE4B (0.57) | PDE4BDDB1CRBNHPGDSKDM4E | |
| SCHEMBL25831682 | 0.80 | DDB1 (0.49) | DDB1CRBNHPGDSJAK2JAK1 | |
| SCHEMBL22609006 | 0.79 | PDE4B (0.57) | PDE4BDDB1CRBNCCNKCDK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125907-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2023-07-06 | — | — | WO | disclosed |