Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 5/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.43 |
| ▸ | CCNB2 | O95067 | 4/20 | 0.43 |
| ▸ | CDK1 | P06493 | 4/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.43 |
| ▸ | CCNB3 | Q8WWL7 | 4/20 | 0.43 |
| ▸ | CDK4 | P11802 | 4/20 | 0.43 |
| ▸ | CCND1 | P24385 | 4/20 | 0.43 |
| ▸ | CAMK2B | Q13554 | 2/20 | 0.43 |
| ▸ | CAMK2G | Q13555 | 2/20 | 0.43 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.43 |
| ▸ | CAMK2A | Q9UQM7 | 2/20 | 0.43 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1004259 | 0.72 | KDR (0.55) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL17867262 | 0.68 | GSK3B (0.46) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL22128354 | 0.68 | HSD17B10 (0.44) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL29397381 | 0.67 | METAP2 (0.52) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL28272924 | 0.67 | METAP2 (0.52) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL181890 | 0.67 | METAP2 (0.52) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL1004766 | 0.66 | MAPT (0.50) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL22122397 | 0.65 | METAP2 (0.40) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL940853 | 0.65 | KDM4E (0.65) | CDK5CDK5R1CCNB2CDK1CCNB1 | |
| SCHEMBL22566990 | 0.65 | CDK4 (0.86) | CDK5CDK5R1CCNB2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125907-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2023-07-06 | — | — | WO | disclosed |