SCHEMBL25830899

SCHEMBL25830899

C=CC(=O)OCCCc1ccc(N(c2ccccc2)c2ccc(-c3ccccc3)cc2)cc1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
THRB P10828 3/20 0.48
LMNA P02545 1/20 0.43
AKR1B10 O60218 2/20 0.43
AKR1B1 P15121 2/20 0.43
TSHR P16473 2/20 0.41
HPGD P15428 1/20 0.41
ALDH1A1 P00352 1/20 0.41
CYP3A4 P08684 1/20 0.41
HDAC2 Q92769 2/20 0.40
FFAR1 O14842 1/20 0.40
NPC1 O15118 1/20 0.40
RECQL P46063 1/20 0.40
RAB9A P51151 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
MGLL Q99685 4/20 0.39
HDAC1 Q13547 1/20 0.39
ALOX5 P09917 1/20 0.39
HCAR2 Q8TDS4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2602486 0.99 THRB (0.49) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL20613617 0.99 THRB (0.49) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL18333495 0.95 THRB (0.52) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL12534108 0.95 THRB (0.52) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL12454726 0.94 THRB (0.47) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL23893938 0.93 THRB (0.44) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL19229845 0.93 THRB (0.44) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL26531998 0.93 THRB (0.44) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL19532025 0.92 THRB (0.50) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL9915739 0.92 THRB (0.50) THRBLMNAAKR1B10AKR1B1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12032318-B2 Electrophotographic image forming system with cleaning blade Konica Minolta, Inc. (JP) 2024-07-09 US disclosed
US-12032318-B2 Electrophotographic image forming system with cleaning blade Konica Minolta, Inc. (JP) 2024-07-09 US disclosed
US-20230185227-A1 ELECTROPHOTOGRAPHIC IMAGE FORMING SYSTEM Konica Minolta, Inc. (JP) 2023-06-15 US disclosed
US-20230185227-A1 ELECTROPHOTOGRAPHIC IMAGE FORMING SYSTEM Konica Minolta, Inc. (JP) 2023-06-15 US disclosed