SCHEMBL20613617

SCHEMBL20613617

C=CC(=O)OCCCc1ccc(N(c2ccccc2)c2ccc(-c3ccc(N(c4ccccc4)c4ccc(CCCOC(=O)C=C)cc4)cc3)cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 3/20 0.49
LMNA P02545 1/20 0.44
AKR1B10 O60218 4/20 0.44
AKR1B1 P15121 4/20 0.44
TSHR P16473 4/20 0.42
HPGD P15428 1/20 0.42
ALDH1A1 P00352 3/20 0.41
CYP3A4 P08684 1/20 0.41
NPC1 O15118 1/20 0.41
RECQL P46063 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
ALOX5 P09917 1/20 0.40
HCAR2 Q8TDS4 1/20 0.40
CHRM5 P08912 1/20 0.38
CHRM1 P11229 1/20 0.38
CHRM3 P20309 1/20 0.38
TP53 P04637 2/20 0.38
HIF1A Q16665 2/20 0.38
HSD17B10 Q99714 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25830899 0.99 THRB (0.48) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL2602486 0.97 THRB (0.49) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL12534108 0.96 THRB (0.52) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL18333495 0.96 THRB (0.52) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL12454726 0.95 THRB (0.47) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL23893938 0.94 THRB (0.44) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL19229845 0.94 THRB (0.44) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL19532025 0.94 THRB (0.50) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL13007033 0.92 THRB (0.51) THRBLMNAAKR1B10AKR1B1TSHR
SCHEMBL2314977 0.92 THRB (0.51) THRBLMNAAKR1B10AKR1B1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3889130-A1 ELECTROCHROMIC ELEMENT Ricoh Company, Ltd. (JP) 2021-10-06 EP disclosed
US-20210301197-A1 ELECTROCHROMIC ELEMENT RICOH COMPANY, LTD. (JP) 2021-09-30 US disclosed
US-20210033992-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2021-02-04 US disclosed
EP-3422106-B1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KK (JP) 2021-01-20 EP disclosed
US-10429754-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2019-10-01 US disclosed
US-10365569-B2 Electrophotographic photosensitive member, production method of electrophotographic photosensitive member, process cartridge and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2019-07-30 US disclosed
US-20190049867-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PRODUCTION METHOD OF ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2019-02-14 US disclosed
EP-3422106-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2019-01-02 EP disclosed