Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.41 |
| ▸ | CDK9 | P50750 | 4/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.38 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30484064 | 1.00 | TBK1 (0.41) | TBK1CDK9BRD4NAMPTGABRP | |
| SCHEMBL30484036 | 0.91 | BRD4 (0.48) | TBK1CDK9BRD4NAMPTGABRP | |
| SCHEMBL25830945 | 0.91 | BRD4 (0.48) | TBK1CDK9BRD4NAMPTGABRP | |
| SCHEMBL25294762 | 0.85 | LIMK1 (0.33) | KIT | |
| SCHEMBL25831072 | 0.85 | TBK1 (0.41) | TBK1CDK9NAMPTGABRPGABRD | |
| SCHEMBL30484047 | 0.85 | TBK1 (0.41) | TBK1CDK9NAMPTGABRPGABRD | |
| SCHEMBL31017627 | 0.84 | CNR1 (0.48) | TBK1CDK9BRD4NAMPTGABRP | |
| SCHEMBL30484043 | 0.84 | CNR1 (0.48) | TBK1CDK9BRD4NAMPTGABRP | |
| SCHEMBL22619097 | 0.80 | RIPK2 (0.42) | TBK1CDK9BRD4NAMPTGABRP | |
| SCHEMBL22619239 | 0.77 | PDK4 (0.43) | TBK1CDK9BRD4NAMPTGABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125907-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2023-07-06 | — | — | WO | disclosed |