Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.41 |
| ▸ | KIT | P10721 | 3/20 | 0.41 |
| ▸ | CDK9 | P50750 | 3/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 3/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.38 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | GABRP | O00591 | 1/20 | 0.36 |
| ▸ | GABRD | O14764 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30484047 | 1.00 | TBK1 (0.41) | TBK1KITCDK9AURKACNR1 | |
| SCHEMBL30484040 | 0.91 | NAMPT (0.47) | TBK1KITCDK9CNR1NAMPT | |
| SCHEMBL30484064 | 0.85 | TBK1 (0.41) | TBK1KITCDK9CNR1NAMPT | |
| SCHEMBL25831065 | 0.85 | TBK1 (0.41) | TBK1KITCDK9CNR1NAMPT | |
| SCHEMBL30484104 | 0.81 | NAMPT (0.35) | TBK1KITCNR1NAMPTKDR | |
| SCHEMBL25831080 | 0.81 | NAMPT (0.35) | TBK1KITCNR1NAMPTKDR | |
| SCHEMBL25427872 | 0.79 | BTK (0.35) | TBK1KITCNR1NAMPTMKNK1 | |
| SCHEMBL25262518 | 0.78 | LIMK1 (0.41) | AURKACNR1 | |
| SCHEMBL22608963 | 0.77 | NAMPT (0.43) | TBK1CNR1NAMPT | |
| SCHEMBL30484036 | 0.76 | BRD4 (0.48) | TBK1KITCDK9CNR1NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125907-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2023-07-06 | — | — | WO | disclosed |