Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 7/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.38 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.36 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6243545 | 0.80 | KAT6A (0.48) | CAPN1LMNALRRK2KDM4EALDH1A1 | |
| SCHEMBL31709951 | 0.80 | LRRK2 (0.47) | CAPN1LMNALRRK2KDM4EALDH1A1 | |
| SCHEMBL8425453 | 0.78 | CAPN1 (0.47) | CAPN1LMNALRRK2KDM4EALDH1A1 | |
| SCHEMBL1785239 | 0.77 | CAPN1 (0.54) | CAPN1LMNALRRK2KDM4EALDH1A1 | |
| SCHEMBL3342457 | 0.77 | LRRK2 (0.47) | CAPN1LMNALRRK2KDM4EALDH1A1 | |
| SCHEMBL28988943 | 0.74 | BCAT2 (0.47) | CAPN1LMNALRRK2KDM4EALDH1A1 | |
| SCHEMBL30411928 | 0.74 | BCAT2 (0.47) | CAPN1LMNALRRK2KDM4EALDH1A1 | |
| SCHEMBL5104519 | 0.74 | CDC7 (0.53) | CAPN1LMNALRRK2KDM4EALDH1A1 | |
| SCHEMBL31173853 | 0.73 | LMNA (0.56) | LMNALRRK2KDM4EALDH1A1MAPK1 | |
| SCHEMBL2161445 | 0.73 | LMNA (0.56) | LMNALRRK2KDM4EALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3880666-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2023-06-28 | — | — | EP | disclosed |