Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | TACR1 | P25103 | 1/20 | 0.46 |
| ▸ | YAP1 | P46937 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30312809 | 0.92 | MEN1 (0.51) | MEN1KMT2ACYP2D6CYP3A4MAPK1 | |
| SCHEMBL14129449 | 0.90 | CHRM2 (0.57) | MEN1KMT2ACHRM2CHRM3CHRM4 | |
| SCHEMBL12004666 | 0.90 | CHRM2 (0.57) | MEN1KMT2ACHRM2CHRM3CHRM4 | |
| SCHEMBL7526966 | 0.90 | CHRM2 (0.57) | MEN1KMT2ACHRM2CHRM3CHRM4 | |
| SCHEMBL30121349 | 0.88 | MEN1 (0.54) | MEN1KMT2ACYP2D6USP2ALDH1A1 | |
| SCHEMBL25134189 | 0.86 | CHRM2 (0.54) | MEN1KMT2ACHRM2CHRM3CHRM4 | |
| SCHEMBL12526355 | 0.83 | CYP2D6 (0.69) | CYP2D6USP2ALDH1A1CYP3A4MAPK1 | |
| SCHEMBL14716132 | 0.83 | ENPP2 (0.56) | MEN1KMT2AUSP2CYP3A4OPRD1 | |
| SCHEMBL2629479 | 0.83 | CYP11B2 (0.53) | MEN1KMT2ACYP2D6ALDH1A1OPRD1 | |
| SCHEMBL2440617 | 0.83 | ENPP2 (0.56) | MEN1KMT2AUSP2CYP3A4OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125907-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2023-07-06 | — | — | WO | disclosed |