Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PANK3 | Q9H999 | 1/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 4/20 | 0.38 |
| ▸ | CTSS | P25774 | 3/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 3/20 | 0.37 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.35 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22389879 | 0.84 | PANK3 (0.50) | PANK3RIPK1CTSSCHRM2ACACB | |
| SCHEMBL28676196 | 0.78 | RET (0.46) | PANK3RIPK1CTSSCHRM2ACACB | |
| SCHEMBL30004676 | 0.78 | RET (0.46) | PANK3RIPK1CTSSCHRM2ACACB | |
| SCHEMBL31421020 | 0.78 | PANK3 (0.49) | PANK3RIPK1HTR1ACTSSACACB | |
| SCHEMBL29324869 | 0.76 | PANK3 (0.48) | PANK3HTR1ACTSSACACBMAPK1 | |
| SCHEMBL28671204 | 0.75 | PANK3 (0.47) | PANK3RIPK1CTSSCHRM2ACACB | |
| SCHEMBL30165199 | 0.74 | ADRB1 (0.55) | PANK3HTR1ACTSKKDM4EALDH1A1 | |
| SCHEMBL16432600 | 0.74 | ADRB1 (0.55) | PANK3HTR1ACTSKKDM4EALDH1A1 | |
| SCHEMBL10845137 | 0.74 | ACHE (0.48) | PANK3RIPK1HTR1ACTSSPTPN11 | |
| SCHEMBL567862 | 0.74 | PIK3CA (0.50) | PANK3ACACBMAPK1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11696916-B2 | Carboxamide-pyrimidine derivatives as SHP2 antagonists | MERCK PATENT GMBH (DE) | 2023-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11696916-B2 | Carboxamide-pyrimidine derivatives as SHP2 antagonists | PTPN5, PTPN2, PTPN1 | PANK3 1328/4885RIPK1 447/4885HTR1A 4127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.