SCHEMBL25834262

SCHEMBL25834262

O=C(Nc1nc2ccc(Nc3cncc(C(F)(F)F)c3)cc2s1)[C@@H]1C2C=CC(C2)[C@@H]1C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.56
CYP2D6 P10635 1/20 0.46
PIK3CD O00329 1/20 0.44
DYRK1A Q13627 1/20 0.42
CSNK1D P48730 4/20 0.41
ABL1 P00519 4/20 0.41
POLB P06746 2/20 0.40
ACP1 P24666 1/20 0.39
CASP6 P55212 1/20 0.39
TDP1 Q9NUW8 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30450142 1.00 ALDH1A1 (0.56) ALDH1A1CYP2D6PIK3CDDYRK1ACSNK1D
SCHEMBL25303127 1.00 ALDH1A1 (0.56) ALDH1A1CYP2D6PIK3CDDYRK1ACSNK1D
SCHEMBL30451004 0.92 ALDH1A1 (0.51) ALDH1A1CYP2D6PIK3CDDYRK1ACSNK1D
SCHEMBL30450379 0.85 ALDH1A1 (0.55) ALDH1A1CYP2D6DYRK1ACSNK1DABL1
SCHEMBL25307365 0.85 ALDH1A1 (0.55) ALDH1A1CYP2D6DYRK1ACSNK1DABL1
SCHEMBL30451396 0.84 ALDH1A1 (0.67) ALDH1A1CYP2D6DYRK1ACSNK1DACP1
SCHEMBL25300056 0.84 ALDH1A1 (0.67) ALDH1A1CYP2D6DYRK1ACSNK1DACP1
SCHEMBL25833329 0.84 ALDH1A1 (0.67) ALDH1A1CYP2D6DYRK1ACSNK1DACP1
SCHEMBL25262799 0.81 ALDH1A1 (0.62) ALDH1A1CYP2D6PIK3CDDYRK1ACSNK1D
SCHEMBL30450160 0.81 ALDH1A1 (0.62) ALDH1A1CYP2D6PIK3CDDYRK1ACSNK1D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023131649-A1 BENZOTHIAZOLE ANAOLOGUES AND USE THEREOF AS BOOSTERS OF ANTI TUBERCULOSIS DRUGS INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) 2023-07-13 WO disclosed