Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.43 |
| ▸ | RELA | Q04206 | 2/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 7/20 | 0.42 |
| ▸ | CACNA1I | Q9P0X4 | 7/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | CACNA1H | O95180 | 6/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21070404 | 0.86 | NPC1 (0.46) | NPC1RAB9AALDH1A1LMNAKDM4E | |
| SCHEMBL6034468 | 0.79 | CACNA1G (0.48) | NPC1RAB9AALDH1A1LMNAKDM4E | |
| SCHEMBL24336213 | 0.71 | CACNA1G (0.42) | NPC1RAB9AALDH1A1LMNAKDM4E | |
| SCHEMBL6031325 | 0.70 | CACNA1G (0.46) | NPC1RAB9AALDH1A1LMNACACNA1G | |
| SCHEMBL18577540 | 0.69 | CYP19A1 (0.48) | NPC1RAB9AALDH1A1LMNAKDM4E | |
| SCHEMBL22149669 | 0.69 | CYP19A1 (0.48) | NPC1RAB9AALDH1A1LMNAKDM4E | |
| SCHEMBL18577609 | 0.69 | CYP19A1 (0.48) | NPC1RAB9AALDH1A1LMNAKDM4E | |
| SCHEMBL10247346 | 0.69 | GFER (0.60) | NPC1RAB9AALDH1A1LMNAKDM4E | |
| SCHEMBL8011610 | 0.69 | CACNA1G (0.51) | NPC1RAB9AALDH1A1LMNAKDM4E | |
| SCHEMBL7862499 | 0.69 | NPC1 (0.49) | NPC1RAB9AALDH1A1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219945-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219945-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | NPC1 3159/4885RAB9A 4270/4885ALDH1A1 2776/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.