Sugi Predict

Sugi Predict / Compounds / SCHEMBL25837795

SCHEMBL25837795

SCHEMBL25837795

CC(C)(C)OC(=O)N1C[C@H](N=[N+]=[N-])C[C@H]1CS(C)(=O)=O

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
▸ MMP2 P08253 2/20 0.41
▸ ANPEP P15144 2/20 0.41
▸ DPP4 P27487 4/20 0.34
▸ DPP8 Q6V1X1 4/20 0.34
▸ DPP9 Q86TI2 4/20 0.34
▸ DPP7 Q9UHL4 4/20 0.34
▸ NR1H2 P55055 4/20 0.33
▸ CYP1A2 P05177 1/20 0.33
▸ POLB P06746 1/20 0.33
▸ CYP3A4 P08684 1/20 0.33
▸ CYP2C19 P33261 1/20 0.33
▸ HSD11B1 P28845 1/20 0.33
▸ NR1H3 Q13133 2/20 0.32
▸ GPR119 Q8TDV5 1/20 0.31
▸ CHRM2 P08172 1/20 0.30
▸ CHRM1 P11229 1/20 0.30
▸ CHRM3 P20309 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24073656 1.00 MMP2 (0.41) MMP2ANPEPDPP4DPP8DPP9
SCHEMBL19910774 0.90 MMP2 (0.44) MMP2ANPEPDPP4DPP8DPP9
SCHEMBL18309960 0.90 MMP2 (0.44) MMP2ANPEPDPP4DPP8DPP9
SCHEMBL28590034 0.90 MMP2 (0.44) MMP2ANPEPDPP4DPP8DPP9
SCHEMBL29269013 0.87 MMP2 (0.40) MMP2ANPEPDPP4DPP8DPP9
SCHEMBL25837797 0.87 MMP2 (0.40) MMP2ANPEPDPP4DPP8DPP9
SCHEMBL22580860 0.87 MMP2 (0.40) MMP2ANPEPDPP4DPP8DPP9
SCHEMBL29269009 0.87 MMP2 (0.40) MMP2ANPEPDPP4DPP8DPP9
SCHEMBL31751090 0.86 MMP2 (0.45) MMP2ANPEPDPP4DPP8DPP9
SCHEMBL18339741 0.85 MMP2 (0.44) MMP2ANPEPDPP4DPP8DPP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4157834-B1 N-(1-CYANO-PYRROLIDIN-3-YL)-5-(3-(TRIFLUOROMETHYL)PHENYL)OXAZOLE-2-CARBOXAMIDE DERIVATIVES AND THE CORRESPONDING OXADIAZOLE DERIVATIVES AS USP30 INHIBITORS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION MISSION THERAPEUTICS LTD (GB) 2024-07-03 — — EP disclosed
US-20230219939-A1 N-(1-CYANO-PYRROLIDIN-3-YL)-5-(3-(TRIFLUOROMETHYL)PHENYL)OXAZOLE-2-CARBOXAMIDE DERIVATIVES AND THE CORRESPONDING OXADIAZOLE DERIVATIVES AS USP30 INHIBITORS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION MISSION THERAPEUTICS LIMITED (GB) 2023-07-13 — — US disclosed
US-20230219939-A1 N-(1-CYANO-PYRROLIDIN-3-YL)-5-(3-(TRIFLUOROMETHYL)PHENYL)OXAZOLE-2-CARBOXAMIDE DERIVATIVES AND THE CORRESPONDING OXADIAZOLE DERIVATIVES AS USP30 INHIBITORS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION MISSION THERAPEUTICS LIMITED (GB) 2023-07-13 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230219939-A1 N-(1-CYANO-PYRROLIDIN-3-YL)-5-(3-(TRIFLUOROMETHYL)PHENYL)OXAZOLE-2-CARBOXAMIDE DERIVATIVES AND THE CORRESPONDING OXADIAZOLE DERIVATIVES AS USP30 INHIBITORS FOR THE TREATMENT OF MITOCHONDRIAL DYSFUNCTION USP30, UQCRC1, NDUFAF1 MMP2 2616/4885ANPEP 2234/4885DPP4 2115/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.