Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | CASP1 | P29466 | 4/20 | 0.47 |
| ▸ | CASP7 | P55210 | 4/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | RGS12 | O14924 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13256237 | 0.93 | CDK5 (0.57) | KDRCDK5CDK5R1MAPTSMN1; SMN2 | |
| SCHEMBL9968963 | 0.85 | MEN1 (0.62) | CDK5CDK5R1MAPTSMN1; SMN2TP53 | |
| SCHEMBL17795644 | 0.81 | PARP1 (0.49) | KDRCDK5CDK5R1MAPTSMN1; SMN2 | |
| SCHEMBL11689659 | 0.79 | USP2 (0.74) | KDRCDK5CDK5R1MAPTSMN1; SMN2 | |
| SCHEMBL8796831 | 0.79 | KDM4E (0.51) | KDRCDK5CDK5R1MAPTKDM4E | |
| SCHEMBL8482582 | 0.79 | KDR (0.48) | KDRCDK5CDK5R1MAPTKDM4E | |
| SCHEMBL29532065 | 0.79 | KDR (0.48) | KDRCDK5CDK5R1MAPTKDM4E | |
| SCHEMBL10955340 | 0.78 | PRMT1 (0.56) | KDRCDK5CDK5R1MAPTSMN1; SMN2 | |
| SCHEMBL10952664 | 0.78 | KDR (0.48) | KDRCDK5CDK5R1MAPTSMN1; SMN2 | |
| SCHEMBL11332532 | 0.78 | MEN1 (0.56) | KDRCDK5CDK5R1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023125877-A1 | TRICYCLIC DERIVATIVE INHIBITOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海翰森生物医药科技有限公司 | 2023-07-06 | — | — | WO | disclosed |