Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.40 |
| ▸ | CDC42BPB | Q9Y5S2 | 7/20 | 0.40 |
| ▸ | CDC42BPA | Q5VT25 | 4/20 | 0.40 |
| ▸ | CHUK | O15111 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.35 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7950769 | 0.76 | MAPK1 (0.39) | ROCK2ROCK1CDC42BPBJAK2JAK3 | |
| SCHEMBL25851514 | 0.73 | MAPK1 (0.37) | JAK2JAK3 | |
| SCHEMBL16946856 | 0.73 | MAPK1 (0.37) | JAK2JAK3 | |
| SCHEMBL13199608 | 0.73 | JAK2 (0.40) | LRRK2JAK2JAK3HSP90AB1 | |
| SCHEMBL14616216 | 0.73 | MAPK1 (0.62) | JAK2JAK3 | |
| SCHEMBL25839070 | 0.70 | SYK (0.37) | JAK2JAK3 | |
| SCHEMBL22201885 | 0.70 | SYK (0.39) | JAK2JAK3 | |
| SCHEMBL2281327 | 0.70 | AAK1 (0.66) | — | |
| SCHEMBL24370189 | 0.69 | SYK (0.36) | JAK2JAK3HSP90AB1 | |
| SCHEMBL12253392 | 0.69 | MAPK1 (0.36) | JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023131122-A1 | FUSED RING-SUBSTITUTED SIX-MEMBERED HETEROCYCLIC COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 劲方医药科技(上海)有限公司 | 2023-07-13 | — | — | WO | disclosed |