Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 1.00 |
| ▸ | CFTR | P13569 | 3/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 6/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA7 | P43166 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29841573 | 0.78 | SOS1 (0.63) | SOS1CFTRNOTUMPDK2MRGPRX4 | |
| SCHEMBL29089686 | 0.78 | SOS1 (0.63) | SOS1CFTRNOTUMPDK2MRGPRX4 | |
| SCHEMBL31439044 | 0.77 | SOS1 (0.62) | SOS1CFTRNOTUMPDK2MRGPRX4 | |
| SCHEMBL28749071 | 0.76 | SOS1 (0.61) | SOS1CFTRNOTUMPDK2MRGPRX4 | |
| SCHEMBL29089727 | 0.74 | SOS1 (0.59) | SOS1CFTRNOTUMPDK2MRGPRX4 | |
| SCHEMBL29841615 | 0.74 | SOS1 (0.59) | SOS1CFTRNOTUMPDK2MRGPRX4 | |
| SCHEMBL2295241 | 0.74 | SOS1 (0.58) | SOS1CFTRNOTUMPDK2MRGPRX4 | |
| SCHEMBL17201188 | 0.73 | SOS1 (0.58) | SOS1CFTRNOTUMPDK2CA12 | |
| SCHEMBL31582812 | 0.73 | SOS1 (0.57) | SOS1CFTRNOTUMPDK2ALDH1A1 | |
| SCHEMBL24457593 | 0.73 | SOS1 (0.57) | SOS1CFTRNOTUMPDK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11702418-B2 | SOS1 inhibitors | Mirati Therapeutics, Inc. (US) | 2023-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11702418-B2 | SOS1 inhibitors | SOS1, SOS2, SOST | SOS1 1/4885CFTR 1688/4885NOTUM 3153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.