Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 4/20 | 0.50 |
| ▸ | F10 | P00742 | 4/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20014214 | 0.92 | F2 (0.48) | F2F10HRH3PDE5A | |
| SCHEMBL13316885 | 0.87 | F2 (0.47) | F2F10HRH3NAMPTHTT | |
| SCHEMBL20014224 | 0.87 | HRH3 (0.48) | F2F10HRH3CTPS1NAMPT | |
| SCHEMBL25840688 | 0.85 | HRH3 (0.47) | F2F10HRH3CTPS1NAMPT | |
| SCHEMBL19814038 | 0.80 | F2 (0.56) | F2F10MAPTALDH1A1 | |
| SCHEMBL3604447 | 0.80 | GSTO1 (0.42) | F2F10HRH3NAMPTHTT | |
| SCHEMBL5601202 | 0.77 | F2 (0.47) | F2F10NAMPTHTTMAPT | |
| SCHEMBL20640302 | 0.77 | F2 (0.55) | F2F10MAPTALDH1A1 | |
| SCHEMBL3538356 | 0.75 | F10 (0.80) | F2F10HRH3MAPTPDE5A | |
| SCHEMBL19820646 | 0.74 | F2 (0.53) | F2F10MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4275759-A2 | QUINOLINE DERIVATIVES AS CHROMOBOX (CBX) PROTEIN INHIBITORS FOR TREATING CANCER | Dana-Farber Cancer Institute, Inc. (US) | 2023-11-15 | — | — | EP | disclosed |
| EP-3515449-B1 | QUINOLINE DERIVATIVES AS CHROMOBOX (CBX) PROTEIN INHIBITORS FOR TREATING CANCER | DANA FARBER CANCER INST INC (US) | 2023-07-12 | — | — | EP | disclosed |