Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | NAMPT | P43490 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GLS | O94925 | 3/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | PRKACA | P17612 | 2/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.37 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25840683 | 0.85 | F2 (0.50) | HRH3NAMPTHTTCTPS1MAPT | |
| SCHEMBL20014224 | 0.84 | HRH3 (0.48) | HRH3NAMPTHTTCTPS1MAPT | |
| SCHEMBL20014214 | 0.78 | F2 (0.48) | HRH3F2F10 | |
| SCHEMBL13316885 | 0.73 | F2 (0.47) | HRH3NAMPTHTTMAPTALDH1A1 | |
| SCHEMBL5476951 | 0.68 | CCNE1 (0.63) | HTTMAPTGLSALDH1A1ADRB2 | |
| SCHEMBL3604447 | 0.66 | GSTO1 (0.42) | HRH3NAMPTHTTMAPTALDH1A1 | |
| SCHEMBL24101797 | 0.64 | ALDH1A1 (0.60) | HTTCTPS1MAPTROCK1PRKACA | |
| SCHEMBL5601202 | 0.64 | F2 (0.47) | NAMPTHTTMAPTROCK1ALDH1A1 | |
| SCHEMBL19814038 | 0.64 | F2 (0.56) | MAPTALDH1A1F2F10 | |
| SCHEMBL20640385 | 0.64 | ACKR3 (0.47) | SIGMAR1F2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515449-B1 | QUINOLINE DERIVATIVES AS CHROMOBOX (CBX) PROTEIN INHIBITORS FOR TREATING CANCER | DANA FARBER CANCER INST INC (US) | 2023-07-12 | — | — | EP | disclosed |