Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25842325 | 0.81 | GAA (0.42) | GAALMNAKDM4EALDH1A1MEN1 | |
| SCHEMBL15174914 | 0.78 | GAA (0.60) | GAALMNAKDM4EALDH1A1MEN1 | |
| SCHEMBL19364028 | 0.76 | SMPD3 (0.42) | SMPD3 | |
| SCHEMBL25842268 | 0.70 | P2RX3 (0.36) | POLBP2RX3P2RX2SMPD3 | |
| SCHEMBL9846110 | 0.70 | GAA (0.55) | GAALMNAKDM4EALDH1A1MEN1 | |
| SCHEMBL18553953 | 0.70 | SOS2 (0.49) | GAAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL20557305 | 0.69 | GAA (0.43) | GAALMNAKDM4EALDH1A1MEN1 | |
| SCHEMBL19363988 | 0.69 | P2RX3 (0.67) | P2RX3P2RX2 | |
| SCHEMBL4077754 | 0.68 | KDM4E (0.51) | GAAKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL25842532 | 0.68 | HTR2A (0.36) | SMPD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3433258-B1 | PYRIMIDINES AND VARIANTS THEREOF, AND USES THEREFOR | AFFERENT PHARMACEUTICALS INC (US) | 2023-07-19 | — | — | EP | disclosed |