Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | EDNRB | P24530 | 1/20 | 0.32 |
| ▸ | EDNRA | P25101 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20013700 | 0.74 | CASR (0.33) | EDNRBEDNRA | |
| SCHEMBL13085751 | 0.74 | ALDH1A1 (0.34) | EDNRBEDNRA | |
| SCHEMBL19998187 | 0.73 | OGA (0.44) | — | |
| SCHEMBL24985274 | 0.72 | MAPT (0.39) | EDNRBEDNRA | |
| SCHEMBL18762866 | 0.71 | CYP2D6 (0.36) | EDNRBEDNRA | |
| SCHEMBL13085699 | 0.69 | ALDH1A1 (0.43) | EDNRBEDNRA | |
| SCHEMBL14318428 | 0.65 | TYR (0.39) | — | |
| SCHEMBL21646563 | 0.63 | SMN1; SMN2 (0.35) | EDNRBEDNRA | |
| SCHEMBL30147946 | 0.63 | SMN1; SMN2 (0.35) | EDNRBEDNRA | |
| SCHEMBL13085710 | 0.63 | POLQ (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227426-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE | AKEBIA THERAPEUTICS, INC. (US) | 2023-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227426-A1 | PHD INHIBITOR COMPOUNDS, COMPOSITIONS, AND USE | HIF1AN, EGLN3, PHF20 | ESR1 4509/4885ESR2 3586/4885EDNRB 196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.