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SCHEMBL25844116

SCHEMBL25844116

Cc1ccc2c(c1)C(C)(C)c1c3c(c4ccccc4c1-2)OC(c1ccc(N2CCOCC2)cc1)(c1ccc2c(c1)C(C)(C)c1ccccc1-2)C=C3

nearest known ligand 0.34

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ PDK2 Q15119 2/20 0.34
▸ ALK Q9UM73 1/20 0.33
▸ MAPT P10636 2/20 0.31
▸ MEN1 O00255 1/20 0.31
▸ LMNA P02545 1/20 0.31
▸ KMT2A Q03164 1/20 0.31
▸ KDM4E B2RXH2 1/20 0.30
▸ ALDH1A1 P00352 1/20 0.30
▸ SMN1; SMN2 Q16637 1/20 0.30
▸ HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25715956 0.96 PDK2 (0.37) PDK2ALKMAPTKDM4EALDH1A1
SCHEMBL25844075 0.94 PDK2 (0.31) PDK2
SCHEMBL25844147 0.94 ALK (0.36) PDK2ALKMAPTMEN1LMNA
SCHEMBL25844136 0.93 PDK2 (0.32) PDK2ALKMAPTMEN1LMNA
SCHEMBL25844130 0.93 MEN1 (0.33) PDK2ALKMAPTMEN1LMNA
SCHEMBL25844138 0.93 MAPT (0.35) PDK2ALKMAPTMEN1LMNA
SCHEMBL3150891 0.92 L3MBTL1 (0.33) PDK2MAPTMEN1LMNAKMT2A
SCHEMBL25844134 0.92 ALK (0.32) ALKMAPTMEN1LMNAKMT2A
SCHEMBL25604302 0.92 PDK2 (0.35) PDK2MAPTKDM4EALDH1A1
SCHEMBL25844128 0.91 ALK (0.32) ALKMAPTMEN1LMNAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230227717-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES HOYA LENS THAILAND LTD. (TH) 2023-07-20 — — US disclosed