SCHEMBL25844767

SCHEMBL25844767

COc1ccc(C2(c3ccc(N4CCOCC4)cc3)C=Cc3c4c(c5ccc(N6CCOCC6)cc5c3O2)-c2ccc(-c3ccc(C)cc3)cc2C4(C)C)cc1

nearest known ligand 0.35

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.35
KMT2A Q03164 4/20 0.35
AKT1 P31749 1/20 0.35
RXFP1 Q9HBX9 2/20 0.34
CHEK1 O14757 1/20 0.33
PRKDC P78527 4/20 0.33
ATM Q13315 1/20 0.33
ALK Q9UM73 1/20 0.33
NR1I2 O75469 1/20 0.33
AHR P35869 1/20 0.33
RAB9A P51151 1/20 0.32
CYP3A4 P08684 1/20 0.31
CYP2D6 P10635 1/20 0.31
CYP2C9 P11712 1/20 0.31
GSK3B P49841 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25844759 0.97 AKT1 (0.33) MEN1KMT2AAKT1RXFP1CHEK1
SCHEMBL25607201 0.94 AKT1 (0.36) MEN1KMT2AAKT1RXFP1CHEK1
SCHEMBL25607202 0.93 AKT1 (0.36) MEN1KMT2AAKT1RXFP1CHEK1
SCHEMBL25844587 0.93 MEN1 (0.34) MEN1KMT2AAKT1RXFP1CHEK1
SCHEMBL9926880 0.92 PRKDC (0.36) MEN1KMT2AAKT1RXFP1CHEK1
SCHEMBL25607205 0.92 MEN1 (0.35) MEN1KMT2AAKT1RXFP1CHEK1
SCHEMBL25607195 0.91 PRKDC (0.36) MEN1KMT2AAKT1PRKDCRAB9A
SCHEMBL25844700 0.91 ALK (0.34) MEN1KMT2APRKDCALKRAB9A
SCHEMBL25607198 0.90 ALDH1A1 (0.35) MEN1KMT2AAKT1CHEK1PRKDC
SCHEMBL25844702 0.90 ALK (0.35) MEN1KMT2APRKDCALKRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230227717-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES HOYA LENS THAILAND LTD. (TH) 2023-07-20 US disclosed