SCHEMBL25607205

SCHEMBL25607205

COc1ccc(C2(c3ccc(N4CCOCC4)cc3)C=Cc3c4c(c5ccc(N6CCOCC6)cc5c3O2)-c2ccc(-c3ccc(C(F)(F)F)cc3)cc2C4(C)C)cc1

nearest known ligand 0.35

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.35
KMT2A Q03164 4/20 0.35
KDM4E B2RXH2 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
RXFP1 Q9HBX9 2/20 0.33
AKT1 P31749 1/20 0.32
CHEK1 O14757 1/20 0.32
LCK P06239 1/20 0.32
CSF1R P07333 1/20 0.32
ATM Q13315 1/20 0.32
NR1I2 O75469 1/20 0.32
AHR P35869 1/20 0.32
PRKDC P78527 4/20 0.32
GSK3B P49841 1/20 0.31
CACNA1G O43497 1/20 0.30
KCNH2 Q12809 1/20 0.30
HTR1A P08908 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3702510 0.97 KDM4E (0.34) MEN1KMT2AKDM4ETDP1AKT1
SCHEMBL1186527 0.94 MEN1 (0.34) MEN1KMT2AKDM4ETDP1RXFP1
SCHEMBL25607024 0.92 LMNA (0.33) MEN1KMT2AKDM4ETDP1LCK
SCHEMBL25607201 0.92 AKT1 (0.36) MEN1KMT2AKDM4ETDP1RXFP1
SCHEMBL25844767 0.92 MEN1 (0.35) MEN1KMT2ARXFP1AKT1CHEK1
SCHEMBL25718161 0.91 LMNA (0.34) MEN1KMT2AKDM4ELCKCSF1R
SCHEMBL1186375 0.91 TNIK (0.33) MEN1KMT2AKDM4ETDP1CHEK1
SCHEMBL26629559 0.91 MEN1 (0.34) MEN1KMT2AKDM4ETDP1RXFP1
SCHEMBL30708927 0.91 CACNA1G (0.33) CHEK1LCKCSF1RGSK3BCACNA1G
SCHEMBL3699961 0.91 CACNA1G (0.33) CHEK1LCKCSF1RGSK3BCACNA1G

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4269532-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES Hoya Lens Thailand Ltd. (TH) 2023-11-01 EP disclosed
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES HOYA LENS THAILAND LTD. (TH) 2023-10-26 US disclosed
US-20230227717-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES HOYA LENS THAILAND LTD. (TH) 2023-07-20 US disclosed
EP-4198102-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES Hoya Lens Thailand Ltd. (TH) 2023-06-21 EP disclosed
EP-4198583-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES Hoya Lens Thailand Ltd. (TH) 2023-06-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES NR2E3, CRY1, RPS10 MEN1 2472/4885KMT2A 2867/4885KDM4E 3270/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.