SCHEMBL25845183

SCHEMBL25845183

COc1ccc(C2(c3ccc4ccccc4c3)C=Cc3c4c(c5ccccc5c3O2)-c2ccc(C(F)(F)F)cc2C4(C)C)cc1

nearest known ligand 0.32

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 1/20 0.32
GABBR2 O75899 1/20 0.32
GABBR1 Q9UBS5 1/20 0.32
CYP2C19 P33261 1/20 0.31
LMNA P02545 1/20 0.31
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25601246 0.96 NR1H4 (0.30) NR1H4
SCHEMBL25713517 0.95 NR1H4 (0.31) NR1H4CYP2C19LMNA
SCHEMBL25601064 0.95 CYP2C19 (0.33) NR1H4CYP2C19LMNA
SCHEMBL25601253 0.94 NR1H4 (0.30) NR1H4
SCHEMBL25601058 0.93 TP53 (0.34) NR1H4CYP2C19LMNA
SCHEMBL25845240 0.93
SCHEMBL25601257 0.93 CYP2C19 (0.31) NR1H4CYP2C19LMNA
SCHEMBL25601790 0.92 NR1H4 (0.34) NR1H4CYP2C19LMNATDP1
SCHEMBL25601673 0.92 KIF11 (0.33) NR1H4CYP2C19LMNA
SCHEMBL25601793 0.92 NR1H4 (0.34) NR1H4CYP2C19LMNATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4270067-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND GLASSES Hoya Lens Thailand Ltd. (TH) 2023-11-01 EP disclosed
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES HOYA LENS THAILAND LTD. (TH) 2023-10-26 US disclosed
US-20230227717-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES HOYA LENS THAILAND LTD. (TH) 2023-07-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES NR2E3, CRY1, RPS10 NR1H4 368/4885GABBR2 2717/4885GABBR1 2709/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.