SCHEMBL2584567

SCHEMBL2584567

Cc1c(S(=O)(=O)c2ccccc2)c2ccccn2c1CC(=O)O

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 3/20 0.52
HCRTR2 O43614 3/20 0.52
PTGDR2 Q9Y5Y4 4/20 0.46
CYP2C9 P11712 2/20 0.41
CYP3A4 P08684 1/20 0.41
PTGDR Q13258 1/20 0.41
KDM4E B2RXH2 3/20 0.40
ALDH1A1 P00352 2/20 0.40
MEN1 O00255 1/20 0.40
MAPT P10636 1/20 0.40
KMT2A Q03164 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
HTR6 P50406 8/20 0.39
KDM4C Q9H3R0 1/20 0.38
HTT P42858 2/20 0.38
CYP19A1 P11511 1/20 0.38
HPGD P15428 1/20 0.38
HSD17B10 Q99714 1/20 0.38
EGLN1 Q9GZT9 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4635639 0.92 HCRTR1 (0.47) HCRTR1HCRTR2PTGDR2CYP2C9CYP3A4
SCHEMBL4635262 0.92 HCRTR1 (0.55) HCRTR1HCRTR2PTGDR2CYP2C9CYP3A4
SCHEMBL2585096 0.82 HCRTR2 (0.74) HCRTR1HCRTR2PTGDR2CYP2C9CYP3A4
SCHEMBL4636277 0.79 HCRTR1 (0.43) HCRTR1HCRTR2PTGDR2KDM4EALDH1A1
SCHEMBL4635636 0.79 HCRTR1 (0.52) HCRTR1HCRTR2PTGDR2CYP2C9CYP3A4
SCHEMBL2594270 0.77 HCRTR2 (0.75) HCRTR1HCRTR2PTGDR2CYP2C9CYP3A4
SCHEMBL2584748 0.75 HCRTR2 (0.63) HCRTR1HCRTR2PTGDR2CYP2C9CYP3A4
SCHEMBL4635948 0.74 ALDH1A1 (0.66) KDM4EALDH1A1MEN1MAPTKMT2A
SCHEMBL4635560 0.72 PTGDR2 (0.46) HCRTR1HCRTR2PTGDR2CYP2C9CYP3A4
SCHEMBL2770132 0.72 ABCB1 (0.44) PTGDR2CYP2C9PTGDRALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011138266-A1 INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS EVOTEC AG (DE) 2011-11-10 WO disclosed