SCHEMBL2584748

SCHEMBL2584748

Cc1c(S(=O)(=O)Cc2cccc(F)c2)c2ccccn2c1CC(=O)O

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCRTR2 O43614 4/20 0.63
HCRTR1 O43613 3/20 0.63
ALDH1A1 P00352 2/20 0.42
HTT P42858 1/20 0.42
LMNA P02545 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
PTGDR Q13258 3/20 0.39
PTGDR2 Q9Y5Y4 3/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2C9 P11712 1/20 0.39
KMT2A Q03164 3/20 0.37
MEN1 O00255 2/20 0.37
GLA P06280 1/20 0.36
TSPO P30536 1/20 0.36
POLB P06746 3/20 0.36
GAA P10253 1/20 0.36
CNR2 P34972 1/20 0.36
KDM4E B2RXH2 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2585096 0.89 HCRTR2 (0.74) HCRTR2HCRTR1ALDH1A1HTTSMN1; SMN2
SCHEMBL2586103 0.89 HCRTR2 (0.58) HCRTR2HCRTR1ALDH1A1HTTLMNA
SCHEMBL2594270 0.88 HCRTR2 (0.75) HCRTR2HCRTR1ALDH1A1SMN1; SMN2NPSR1
SCHEMBL7701854 0.84 HCRTR2 (0.86) HCRTR2HCRTR1ALDH1A1HTTLMNA
SCHEMBL7707551 0.82 HCRTR2 (0.71) HCRTR2HCRTR1ALDH1A1HTTLMNA
SCHEMBL2584750 0.80 HCRTR2 (0.48) HCRTR2HCRTR1ALDH1A1HTTLMNA
SCHEMBL2589693 0.79 HCRTR2 (0.47) HCRTR2HCRTR1ALDH1A1HTTLMNA
SCHEMBL7710724 0.78 HCRTR2 (0.70) HCRTR2HCRTR1ALDH1A1HTTSMN1; SMN2
SCHEMBL7710901 0.77 HCRTR2 (1.00) HCRTR2HCRTR1ALDH1A1LMNANPSR1
SCHEMBL2588741 0.77 HCRTR2 (0.71) HCRTR2HCRTR1ALDH1A1HTTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011138266-A1 INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS EVOTEC AG (DE) 2011-11-10 WO disclosed
WO-2011138266-A1 INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS EVOTEC AG (DE) 2011-11-10 WO disclosed