Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR2 | O43614 | 4/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2589762 | 0.89 | HCRTR2 (0.57) | HCRTR2HCRTR1ALDH1A1HTTHSD17B10 | |
| SCHEMBL2586103 | 0.82 | HCRTR2 (0.58) | HCRTR2HCRTR1ALDH1A1HTTHSD17B10 | |
| SCHEMBL2592298 | 0.81 | HCRTR2 (0.45) | HCRTR2HCRTR1ALDH1A1HTTHSD17B10 | |
| SCHEMBL2584750 | 0.80 | HCRTR2 (0.48) | HCRTR2HCRTR1ALDH1A1HTTHSD17B10 | |
| SCHEMBL2589631 | 0.79 | HCRTR2 (0.56) | HCRTR2HCRTR1ALDH1A1HTTHSD17B10 | |
| SCHEMBL2584748 | 0.79 | HCRTR2 (0.63) | HCRTR2HCRTR1ALDH1A1HTTHSD17B10 | |
| SCHEMBL4636242 | 0.77 | MAPT (0.45) | HCRTR2HCRTR1ALDH1A1HTTHSD17B10 | |
| SCHEMBL7701854 | 0.72 | HCRTR2 (0.86) | HCRTR2HCRTR1ALDH1A1HTTLMNA | |
| SCHEMBL4636941 | 0.71 | ALDH1A1 (0.42) | ALDH1A1HTTHSD17B10KDM4EHPGD | |
| SCHEMBL2588741 | 0.71 | HCRTR2 (0.71) | HCRTR2HCRTR1ALDH1A1HTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011138266-A1 | INDOLIZINE AND IMIDAZOPYRIDINE DERIVATIVES AS OREXIN RECEPTOR ANTAGONISTS | EVOTEC AG (DE) | 2011-11-10 | — | — | WO | disclosed |