Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 5/20 | 0.80 |
| ▸ | MERTK | Q12866 | 5/20 | 0.67 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.57 |
| ▸ | PDE5A | O76074 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2590759 | 0.89 | NPY5R (0.76) | NPY5RSLC2A1MAPTMAPK1MEN1 | |
| SCHEMBL8909187 | 0.89 | NPY5R (1.00) | NPY5RMERTKSLC2A1MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL8907334 | 0.88 | NPY5R (0.83) | NPY5RMERTKSLC2A1MAPTMAPK1 | |
| SCHEMBL2587936 | 0.88 | NPY5R (0.84) | NPY5RMAPTMEN1KMT2ANPC1 | |
| Hydrochloric Acid SCHEMBL8900478 | 0.88 | NPY5R (0.97) | NPY5RMERTKSLC2A1MAPTMAPK1 | |
| SCHEMBL2590796 | 0.88 | NPY5R (0.97) | NPY5RMERTKSLC2A1MAPTMAPK1 | |
| SCHEMBL2592190 | 0.87 | NPY5R (0.78) | NPY5RSLC2A1MAPTMAPK1MEN1 | |
| Hydrochloric Acid SCHEMBL8897702 | 0.87 | NPY5R (0.94) | NPY5RMERTKSLC2A1MAPTMAPK1 | |
| SCHEMBL2590586 | 0.86 | SLC2A1 (0.73) | NPY5RMERTKSLC2A1TP53PDE5A | |
| SCHEMBL8891851 | 0.86 | NPY5R (0.78) | NPY5RMERTKMAPTMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566480-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | California Institute of Technology (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |