Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.73 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.63 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.58 |
| ▸ | APP | P05067 | 2/20 | 0.58 |
| ▸ | MERTK | Q12866 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | PDE5A | O76074 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.55 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2590464 | 0.91 | SLC2A1 (0.66) | SLC2A1SOS1KDM4EHTTTAAR1 | |
| SCHEMBL2588890 | 0.89 | SOS1 (0.70) | SLC2A1SOS1NPY5RKDM4EAPP | |
| SCHEMBL2583209 | 0.89 | SOS1 (0.72) | SLC2A1SOS1KDM4EHTTAPP | |
| SCHEMBL2588902 | 0.89 | SOS1 (0.66) | SLC2A1SOS1NPY5RKDM4EHTT | |
| SCHEMBL2587225 | 0.86 | SOS1 (0.66) | SLC2A1SOS1KDM4EHTTAPP | |
| SCHEMBL2590218 | 0.86 | SOS1 (0.66) | SOS1KDM4EAPPMERTKPDE5A | |
| SCHEMBL2584929 | 0.86 | NPY5R (0.80) | SLC2A1NPY5RKDM4EHTTTAAR1 | |
| SCHEMBL2592287 | 0.86 | SOS1 (0.71) | SLC2A1SOS1NPY5RKDM4EAPP | |
| SCHEMBL12175852 | 0.85 | SLC2A1 (1.00) | SLC2A1NPY5RKDM4EAPPMERTK | |
| SCHEMBL2587500 | 0.84 | SLC2A1 (0.65) | SLC2A1SOS1KDM4EHTTTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566480-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | California Institute of Technology (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |
| WO-2011140527-A2 | METHODS AND COMPOSITIONS FOR INHIBITION OF THE TRANSITIONAL ENDOPLASMIC RETICULUM ATPASE | CALIFORNIA INSTITUTE OF TECHNOLOGY AND THE UNIVERSITY OF KANSAS (US) | 2011-11-10 | — | — | WO | disclosed |