SCHEMBL25849618

SCHEMBL25849618

COc1cc2c3c(c4c(c2cc1OC)-c1ccc(C#N)cc1C4(C)C)C=CC(c1ccccc1)(c1ccc(N2CCOCC2)cc1)O3

nearest known ligand 0.42

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALK Q9UM73 16/20 0.42
TNIK Q9UKE5 3/20 0.38
KIT P10721 2/20 0.37
KDR P35968 2/20 0.37
TBK1 Q9UHD2 1/20 0.35
KCNH2 Q12809 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25849573 0.97 ALK (0.44) ALKTNIKKITKDRTBK1
SCHEMBL25716666 0.96 ALK (0.40) ALKTNIKKITKDRTBK1
SCHEMBL25716669 0.94 ALK (0.42) ALKTNIKKITKDRTBK1
SCHEMBL25716662 0.93 ALK (0.42) ALKTNIKKITKDRTBK1
SCHEMBL25851749 0.91 ALK (0.42) ALKTNIKKITKDRTBK1
SCHEMBL25602404 0.91 ALK (0.45) ALKKITKDRTBK1
SCHEMBL25717158 0.91 TNIK (0.36) ALKTNIKKITKDRTBK1
SCHEMBL25849620 0.90 ALK (0.40) ALKTNIKKITKDRTBK1
SCHEMBL25844451 0.90 ALK (0.33) ALK
SCHEMBL29453309 0.89 STK10 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES HOYA LENS THAILAND LTD. (TH) 2023-10-26 US disclosed
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES HOYA LENS THAILAND LTD. (TH) 2023-10-26 US disclosed
US-20230227717-A1 PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND SPECTACLES HOYA LENS THAILAND LTD. (TH) 2023-07-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230340318-A1 PHOTOCHROMIC COMPOUND, PHOTOCHROMIC COMPOSITION, PHOTOCHROMIC ARTICLE, AND EYEGLASSES NR2E3, CRY1, RPS10 ALK 2627/4885TNIK 4867/4885KIT 4361/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.