SCHEMBL25849731

SCHEMBL25849731

CN1c2ccccc2C(C)(C)c2c1ccc1cc(/C=C3\C(=O)c4ccccc4C3=C(C#N)C#N)ccc21

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 13/20 0.36
MEN1 O00255 12/20 0.36
MAPT P10636 10/20 0.36
HTT P42858 4/20 0.36
USP2 O75604 3/20 0.36
RAB9A P51151 2/20 0.36
SMN1; SMN2 Q16637 2/20 0.36
POLB P06746 2/20 0.36
NPC1 O15118 1/20 0.36
CRHBP P24387 3/20 0.36
CRHR2 Q13324 3/20 0.36
KEAP1 Q14145 1/20 0.36
NFE2L2 Q16236 1/20 0.36
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
CYP2C19 P33261 1/20 0.35
LCK P06239 1/20 0.33
ALDH1A1 P00352 6/20 0.33
EGFR P00533 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25849739 0.94 MEN1 (0.39) KMT2AMEN1MAPTHTTUSP2
SCHEMBL25849789 0.89 MAPT (0.42) KMT2AMEN1MAPTHTTUSP2
SCHEMBL25165243 0.88 KMT2A (0.40) KMT2AMEN1MAPTHTTUSP2
SCHEMBL17779029 0.84 PSMB2 (0.30)
SCHEMBL25849707 0.83 MAPT (0.39) KMT2AMEN1MAPTHTTUSP2
SCHEMBL25849963 0.82 ALDH1A1 (0.34) KMT2AMEN1MAPTHTTSMN1; SMN2
SCHEMBL17427159 0.82 ALDH1A1 (0.32) KMT2AMEN1MAPTHTTSMN1; SMN2
SCHEMBL25851280 0.81 KDM4E (0.30) KMT2AMEN1MAPTALDH1A1KDM4E
SCHEMBL25849742 0.81 MEN1 (0.44) KMT2AMEN1MAPTHTTUSP2
SCHEMBL25850600 0.79 LCK (0.37) KMT2AMEN1MAPTHTTUSP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230232713-A1 PHOTOELECTRIC CONVERSION ELEMENT, IMAGING ELEMENT, OPTICAL SENSOR, AND COMPOUND FUJIFILM CORPORATION (JP) 2023-07-20 US disclosed