Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | GFER | P55789 | 1/20 | 0.63 |
| ▸ | PADI4 | Q9UM07 | 4/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25849885 | 0.87 | KDM4E (0.64) | PIM1KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL22910882 | 0.85 | KDM4E (0.65) | PIM1KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL24095581 | 0.82 | KDM4E (0.79) | PIM1KDM4EALDH1A1HSD17B10MEN1 | |
| SCHEMBL29612310 | 0.82 | PADI4 (0.73) | PIM1KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL19952906 | 0.82 | PADI4 (0.73) | PIM1KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL29709937 | 0.81 | MAPT (0.75) | KDM4EALDH1A1HPGDPADI4MAPT | |
| SCHEMBL5396117 | 0.81 | MAPT (0.75) | KDM4EALDH1A1HPGDPADI4MAPT | |
| SCHEMBL25849874 | 0.80 | KDM4E (0.60) | PIM1KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL25849868 | 0.80 | KDM4E (0.74) | PIM1KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL16111563 | 0.80 | PIM1 (1.00) | PIM1KDM4EALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230227409-A1 | QUINOLINONE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS | IDEAYA BIOSCIENCES, INC. | 2023-07-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230227409-A1 | QUINOLINONE DERIVATIVES AS METHIONINE ADENOSYLTRANSFERASE 2A INHIBITORS | MAT2B, MAT2A, MAT1A | PIM1 3723/4885KDM4E 1392/4885ALDH1A1 607/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.