Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2579399 | 0.79 | SMN1; SMN2 (0.59) | LMNASMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL4274149 | 0.79 | ALDH1A1 (0.48) | LMNASMN1; SMN2KMT2ATSHRNPC1 | |
| SCHEMBL13545781 | 0.76 | KMT2A (1.00) | LMNASMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL2582126 | 0.74 | SMN1; SMN2 (0.54) | LMNASMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL15321664 | 0.71 | ALDH1A1 (0.62) | LMNASMN1; SMN2TSHRRAB9AHPGD | |
| SCHEMBL13545775 | 0.71 | LMNA (0.69) | LMNASMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL15300410 | 0.70 | ALDH1A1 (0.47) | LMNASMN1; SMN2KMT2ATSHRNPC1 | |
| SCHEMBL4263116 | 0.68 | LMNA (0.56) | LMNASMN1; SMN2KMT2ATSHRNPC1 | |
| SCHEMBL2588184 | 0.67 | MAPT (0.63) | LMNASMN1; SMN2KMT2ATSHRNPC1 | |
| SCHEMBL4263699 | 0.66 | MAPT (0.60) | LMNASMN1; SMN2KMT2AMEN1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |