Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 15/20 | 0.46 |
| ▸ | GSK3B | P49841 | 14/20 | 0.46 |
| ▸ | GSK3A | P49840 | 4/20 | 0.46 |
| ▸ | CDK9 | P50750 | 3/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10923229 | 0.85 | CRBN (0.43) | CDK5GSK3BGSK3ACDK9CHEK1 | |
| SCHEMBL31032294 | 0.78 | CDK5 (0.48) | CDK5GSK3BGSK3ACDK9CHEK1 | |
| SCHEMBL10923189 | 0.71 | TP53 (0.39) | CDK5GSK3BGSK3ACDK9CHEK1 | |
| SCHEMBL25853873 | 0.70 | ACVR1 (0.49) | GSK3BABL1METCDK8DYRK1A | |
| SCHEMBL31380022 | 0.70 | ACVR1 (0.49) | GSK3BABL1METCDK8DYRK1A | |
| SCHEMBL25853870 | 0.70 | DYRK1A (0.44) | GSK3BDYRK1A | |
| SCHEMBL25853872 | 0.70 | ACVR1 (0.46) | GSK3BABL1DYRK1A | |
| SCHEMBL29124061 | 0.70 | CDK5 (0.47) | CDK5GSK3BGSK3ACDK9CDK5R1 | |
| SCHEMBL7594487 | 0.69 | CYP11B1 (0.42) | KDRALDH1A1PARP1PRKCIPDE4B | |
| SCHEMBL13854136 | 0.68 | CDK9 (0.66) | CDK5GSK3BGSK3ACDK9CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107723-A2 | METHODS FOR TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |