Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 5/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25852792 | 0.85 | CDK5 (0.46) | CRBNDDB1ALDH1A1HSD17B10PARP1 | |
| SCHEMBL7594487 | 0.77 | CYP11B1 (0.42) | CRBNDDB1ALDH1A1HSD17B10PARP1 | |
| SCHEMBL10919563 | 0.75 | CRBN (0.38) | CRBNDDB1ALDH1A1HSD17B10PARP1 | |
| SCHEMBL18576434 | 0.73 | KDM4E (0.47) | ALDH1A1HSD17B10PARP1PRKCIPDE4B | |
| SCHEMBL10379077 | 0.72 | UHRF1 (0.40) | ALDH1A1HSD17B10PARP1PRKCIPDE4B | |
| SCHEMBL8944351 | 0.71 | CYP2C19 (0.47) | CRBNDDB1ALDH1A1HSD17B10CYP2C19 | |
| SCHEMBL10923189 | 0.70 | TP53 (0.39) | CRBNDDB1ALDH1A1HSD17B10PARP1 | |
| SCHEMBL10526975 | 0.70 | CCNB2 (0.42) | CRBNDDB1PARP1TDP1CDK5 | |
| SCHEMBL29374271 | 0.67 | ACHE (0.46) | ALDH1A1HSD17B10TDP1CYP2C19CYP2D6 | |
| SCHEMBL8088682 | 0.67 | ACHE (0.46) | ALDH1A1HSD17B10CYP2C19CYP2D6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167045-A1 | Benzo[c][1,8]naphthyridines, process for their preparation and their use, and compositions containing these compounds | Beiersdorf Aktiengesellschaft (DE) | 1986-01-08 | — | — | EP | claimed |
| EP-0167045-A1 | Benzo[c][1,8]naphthyridines, process for their preparation and their use, and compositions containing these compounds | Beiersdorf Aktiengesellschaft (DE) | 1986-01-08 | — | — | EP | disclosed |