Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4264844 | 0.81 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2GAAKMT2A | |
| SCHEMBL4264840 | 0.81 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2GAAKMT2A | |
| SCHEMBL2590810 | 0.81 | HSP90AA1 (0.53) | HSP90AA1RAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL2579127 | 0.80 | RAB9A (0.45) | HSP90AA1RAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL2589526 | 0.78 | SMN1; SMN2 (0.48) | HSP90AA1RAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL2582339 | 0.76 | HSP90AA1 (0.49) | HSP90AA1RAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL5532889 | 0.73 | RAB9A (0.46) | RAB9ANPC1SMN1; SMN2GAAKMT2A | |
| SCHEMBL2586733 | 0.72 | HSP90AA1 (0.46) | HSP90AA1SMN1; SMN2HDAC3HDAC4HDAC1 | |
| SCHEMBL2575999 | 0.72 | HSP90AA1 (0.46) | HSP90AA1RAB9ANPC1SMN1; SMN2GAA | |
| SCHEMBL2580861 | 0.72 | HSP90AA1 (0.47) | HSP90AA1RAB9AHDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | claimed |
| US-8048879-B2 | Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments | GRUENENTHAL GMBH (DE) | 2011-11-01 | — | — | US | disclosed |