SCHEMBL2575999

SCHEMBL2575999

CN(C)CCNC(=O)c1noc2c1CN(C(=O)c1cccc(SC(F)F)c1)CC2

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 12/20 0.46
HDAC3 O15379 1/20 0.43
HDAC4 P56524 1/20 0.43
HDAC1 Q13547 1/20 0.43
HDAC7 Q8WUI4 1/20 0.43
HDAC2 Q92769 1/20 0.43
HDAC10 Q969S8 1/20 0.43
HDAC11 Q96DB2 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
HDAC5 Q9UQL6 1/20 0.43
NCOR2 Q9Y618 1/20 0.43
GAA P10253 2/20 0.37
ALDH1A1 P00352 2/20 0.37
SMN1; SMN2 Q16637 2/20 0.37
NPC1 O15118 2/20 0.37
RAB9A P51151 2/20 0.37
AKR1C3 P42330 1/20 0.36
KMT2A Q03164 1/20 0.36
LMNA P02545 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4267314 0.83 NPC1 (0.40) HSP90AA1ALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL2586733 0.82 HSP90AA1 (0.46) HSP90AA1HDAC3HDAC4HDAC1HDAC7
SCHEMBL2582339 0.78 HSP90AA1 (0.49) HSP90AA1HDAC3HDAC4HDAC1HDAC7
SCHEMBL5526654 0.76 ALDH1A1 (0.35) HSP90AA1ALDH1A1SMN1; SMN2NPC1RAB9A
SCHEMBL2586734 0.76 HSP90AA1 (0.55) HSP90AA1HDAC3HDAC4HDAC1HDAC7
SCHEMBL2580861 0.73 HSP90AA1 (0.47) HSP90AA1HDAC3HDAC4HDAC1HDAC7
SCHEMBL2585600 0.72 HSP90AA1 (0.45) HSP90AA1HDAC3HDAC4HDAC1HDAC7
SCHEMBL2579127 0.72 RAB9A (0.45) HSP90AA1HDAC3HDAC4HDAC1HDAC7
SCHEMBL2579206 0.72 HSP90AA1 (0.52) HSP90AA1HDAC3HDAC4HDAC1HDAC7
SCHEMBL2589526 0.70 SMN1; SMN2 (0.48) HSP90AA1HDAC3HDAC4HDAC1HDAC7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8048879-B2 Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments GRUENENTHAL GMBH (DE) 2011-11-01 US claimed
US-8048879-B2 Substituted 4,5,6,7-tetrahydro-isoxazolo[4,5-c]pyridine compounds and use thereof for producing medicaments GRUENENTHAL GMBH (DE) 2011-11-01 US disclosed