SCHEMBL25856312

SCHEMBL25856312

CC(C)N1CCC(N2CCC(CN3CCN(C)CC3)CC2)CC1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 6/20 0.40
CACNA2D1 P54289 1/20 0.36
CACNA1B Q00975 1/20 0.36
CACNB1 Q02641 1/20 0.36
CACNA1C Q13936 1/20 0.36
POLB P06746 1/20 0.36
L3MBTL3 Q96JM7 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
ACHE P22303 1/20 0.32
NCF1 P14598 1/20 0.32
CHRM5 P08912 1/20 0.32
ADRA2C P18825 1/20 0.32
LMNA P02545 2/20 0.31
MEN1 O00255 1/20 0.31
MAPT P10636 1/20 0.31
KMT2A Q03164 1/20 0.31
TLR9 Q9NR96 1/20 0.30
TLR8 Q9NR97 1/20 0.30
TLR7 Q9NYK1 1/20 0.30
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25122598 0.94 CACNA2D1 (0.39) HRH3CACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL24233101 0.90 POLB (0.36) HRH3POLBACHECHRM5ADRA2C
SCHEMBL13300929 0.90 HRH3 (0.46) HRH3CACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL19312863 0.87 POLB (0.36) HRH3POLBACHECHRM5ADRA2C
SCHEMBL22102443 0.85 CACNA2D1 (0.34) HRH3CACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL25605624 0.84 ACHE (0.50) HRH3POLBACHECHRM5ADRA2C
SCHEMBL10092712 0.83 CACNA2D1 (0.43) HRH3CACNA2D1CACNA1BCACNB1CACNA1C
SCHEMBL25123775 0.83 KMT2A (0.40) HRH3POLBL3MBTL1ACHEKMT2A
SCHEMBL29317411 0.83 POLB (0.35) HRH3CACNA2D1CACNA1BCACNB1POLB
SCHEMBL25600510 0.83 OPRL1 (0.39) POLBACHETLR9TLR8TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023131167-A1 COMPOUND FOR INHIBITING AND DEGRADING IRAK4, AND PHARMACEUTICAL COMPOSITION AND PHARMACEUTICAL APPLICATION THEREOF 海思科医药集团股份有限公司 2023-07-13 WO disclosed