Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.37 |
| ▸ | ERN1 | O75460 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2952488 | 0.83 | KDM4E (0.47) | KDM4EMAPKAPK2HTTPOLBRAD52 | |
| SCHEMBL4439957 | 0.75 | IMPDH2 (0.40) | KDM4EMAPKAPK2HTTPOLBRAD52 | |
| SCHEMBL29560021 | 0.75 | KDM4E (0.43) | KDM4EMAPKAPK2HTTPOLBRAD52 | |
| SCHEMBL19153319 | 0.75 | MAOA (0.37) | KDM4EMAPKAPK2HTTPOLBRAD52 | |
| SCHEMBL30502555 | 0.75 | MAOA (0.37) | KDM4EMAPKAPK2HTTPOLBRAD52 | |
| SCHEMBL276690 | 0.74 | CLK1 (0.44) | KDM4EMAPKAPK2HTTPOLBRAD52 | |
| Phthalazinone SCHEMBL276919 | 0.74 | NPC1 (0.52) | KDM4ELMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL3690210 | 0.73 | EP300 (0.47) | KDM4EMAPKAPK2POLBEP300KAT2B | |
| Phthalazinone SCHEMBL11770591 | 0.72 | KDM4E (0.53) | KDM4ELMNACYP1A2CYP3A4CYP2D6 | |
| Bromide SCHEMBL3826333 | 0.72 | CLK1 (0.43) | KDM4EMAPKAPK2HTTPOLBRAD52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4499638-A1 | PYRIDO-[3,4-D]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 DERIVATIVES | Ventus Therapeutics U.S., Inc. (US) | 2025-02-05 | — | — | EP | disclosed |
| WO-2023183943-A1 | PYRIDO-[3,4-D]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 DERIVATIVES | VENTUS THERAPEUTICS U.S., INC. (US) | 2023-09-28 | — | — | WO | disclosed |
| WO-2023131277-A1 | NLRP3 INFLAMMASOME INHIBITOR AND USES THEREOF | 药捷安康(南京)科技股份有限公司 | 2023-07-13 | — | — | WO | disclosed |