Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 13/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | P62805 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25308682 | 0.79 | BRD4 (0.46) | KDM4EADORA2AADORA1ALDH1A1GAA | |
| SCHEMBL29435907 | 0.79 | BRD4 (0.46) | KDM4EADORA2AADORA1ALDH1A1GAA | |
| SCHEMBL25306779 | 0.78 | ADORA2A (0.58) | ADORA2AADORA1 | |
| SCHEMBL25857612 | 0.76 | TOP2A (0.52) | TOP2AKDM4ESMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL25858412 | 0.75 | ADORA2A (0.64) | TOP2AKDM4ESMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL2816349 | 0.73 | KDM4E (0.63) | TOP2AKDM4ESMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL29435897 | 0.71 | ADORA2A (0.40) | ADORA2AADORA1 | |
| SCHEMBL15722446 | 0.71 | BRD4 (0.44) | TOP2ABRD4H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | |
| SCHEMBL2820509 | 0.70 | TOP2A (0.52) | TOP2AKDM4ESMN1; SMN2ADORA2AADORA1 | |
| SCHEMBL2816600 | 0.70 | TOP2A (0.52) | TOP2AKDM4ESMN1; SMN2ADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023130701-A1 | 1-AMINOBENZO[4,5]IMIDAZO[1,2-A]PYRAZINE-3-FORMAMIDE COMPOUND, AND PREPARATION THEREFOR AND USE THEREOF | 中山大学 | 2023-07-13 | — | — | WO | disclosed |