Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 4/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25859739 | 0.86 | MAPT (0.39) | MAPTESR2NR1H2ACACBMKNK1 | |
| SCHEMBL25304050 | 0.72 | HTR6 (0.39) | MAPTESR2NR1H2ACACBMKNK1 | |
| SCHEMBL30381434 | 0.72 | HTR6 (0.39) | MAPTESR2NR1H2ACACBMKNK1 | |
| SCHEMBL25428616 | 0.72 | MAPT (0.45) | MAPTESR2NR1H2ACACBADORA1 | |
| SCHEMBL30380944 | 0.72 | MAPT (0.45) | MAPTESR2NR1H2ACACBADORA1 | |
| SCHEMBL2487129 | 0.71 | MAPT (0.46) | MAPTESR2NR1H2ACACBADORA1 | |
| SCHEMBL31164759 | 0.69 | MAPT (0.51) | MAPTESR2NR1H2SCN9APARP1 | |
| SCHEMBL20364331 | 0.69 | ESR2 (0.61) | MAPTESR2NR1H2MAPK1NAMPT | |
| SCHEMBL2487072 | 0.69 | PARP1 (0.45) | MAPTESR2NR1H2MKNK1SCN9A | |
| SCHEMBL2486452 | 0.68 | NR1H2 (0.51) | MAPTESR2NR1H2ACACBADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023107723-A2 | METHODS FOR TREATING NEUROLOGICAL DISORDERS | PROTHENA BIOSCIENCES LIMITED (IE) | 2023-06-15 | — | — | WO | disclosed |